[英文釋義] The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology,1st ed)
This paper summarizes studies for phase clinical trials . it mainly introduces different, methods about determining maximum tolerated dose ( mtd ) and proposes further subjects for future research 摘要本文綜述關(guān)于期臨床試驗的研究。主要介紹確定最大耐受劑量(mtd)的不同方法,以及提出可以進(jìn)一步進(jìn)行研究的問題。